Xi-Long Zheng, PhD, MD
PhD in Pharmacology Cumming School of Medicine University of Calgary
Areas of Research
Molecular Mechanisms Underlying the Pathogenesis of Cardiovascular Disease
RESEARCH PROJECTS FOR GRADUATES 1) Investigate the roles of autophagy in vascular smooth muscle. Approach: Smooth muscle-specific knockout of Atg7. Outcome: a vascular premature aging mouse model. 2) Study the role of PCSK9 in vascular smooth muscle. Approach: Smooth muscle-specific knockin and knockout. Outcome: A new therapeutic target of atherosclerosis. 3) Explore the protective role against atherosclerosis of MCPIP1, an RNA binding protein, in vascular smooth muscle. Approach: Smooth muscle-specific knockin and knockout. Outcome: A new therapeutic target of atherosclerosis. 4) Investigate the regulatory effects of estrogen metabolites and a novel endothelium-derived contraction factor, uridine adenosine tetraphosphate (Up4A), on the vascular system. Approach: Hypertension and atherosclerosis animal models. Outcome: New drug discovery.
RESEARCH PROJECTS FOR GRADUATES 1) Investigate the roles of autophagy in vascular smooth muscle. Approach: Smooth muscle-specific knockout of Atg7. Outcome: a vascular premature aging mouse model. 2) Study the role of PCSK9 in vascular smooth muscle. Approach: Smooth muscle-specific knockin and knockout. Outcome: A new therapeutic target of atherosclerosis. 3) Explore the protective role against atherosclerosis of MCPIP1, an RNA binding protein, in vascular smooth muscle. Approach: Smooth muscle-specific knockin and knockout. Outcome: A new therapeutic target of atherosclerosis. 4) Investigate the regulatory effects of estrogen metabolites and a novel endothelium-derived contraction factor, uridine adenosine tetraphosphate (Up4A), on the vascular system. Approach: Hypertension and atherosclerosis animal models. Outcome: New drug discovery.
Supervising degrees
Biochemistry and Molecular Biology - Doctoral: Accepting Inquiries
Biochemistry and Molecular Biology - Masters: Accepting Inquiries
Cardiovascular and Respiratory Sciences - Doctoral: Accepting Inquiries
Cardiovascular and Respiratory Sciences - Masters: Accepting Inquiries
More information
Working with this supervisor
Highly Motivated Candidates With Strong Background in One of the Following Areas: Pathology, Physiology, Pharmacology, Biochemistry, Molecular or Cell Biology.
Contact this supervisor
Complete the following form if you are interested in working with this supervisor for your Graduate Program. All fields are required, unless indicated otherwise.
Collection of personal information
Your personal information is collected under
the authority of section 33(c) of the Freedom of Information and Protection of Privacy Act. If
you have any questions about the collection or use of this information, please visit our
Access to Information page.