The lymphatic system and its roles in inflammation and inflammatory diseases
The lymphatic system is composed of a dense network of lymphatic vessels, which plays a vital role in physiological processes such as tissue fluid homeostasis and transport of antigens and immune cells to and from lymphoid tissue. These functions are critically important during inflammation to minimize the associated edema and initiate the immune response. My research program is focused on the physiology of lymphatic vessels and mechanisms related to the propulsion of lymph and alteration of these functions during inflammation. We are investigating the mechanisms whereby lymphatic pumping, the means to drain lymph, is generated and how it is modulated by mechanical and chemical means in health and disease.