Autism, Fragile X Syndrome, Translational studies on neurodevelopmental disorders using animal models
Autism is one of the most prevalent neurodevelopmental disorders both in Canada and worldwide. It causes significant social, communication and behavioral challenges. Currently, effective supporting approaches are extremely limited for autism. The overarching goal of our research program is to elucidate the mechanisms underlying the symptoms and to identify potential therapeutics, with a particular interest in the Extracellular signal-Regulated Kinases (ERK) signaling. To achieve this goal, we utilize animal models of autism and related disorders such as Fragile X Syndrome. We perform in vivo recording and modulation of brain activities, combined with simultaneous behavioral assessment. In addition, we collect tissue for biochemical, molecular, and anatomical analysis. Using these methods, we test the efficacy of pharmacological treatment with clinically relevant reagents. Of the many areas relevant to neurodevelopmental conditions, we are particularly interested in social interactions and sensory (auditory) processing. We have developed advanced tools through multidisciplinary collaborations to probe mechanisms and create new interventions. Through these translational studies with the integrative approach we have established, our goal is to better understand autism and related disorders and contribute to advance novel approaches to help affected individuals.